Coursebook on law and neuroscience, including the bearing of neuroscience on criminal law, criminal procedure, and evidence.

This work was originally published in 1902 & marked a watershed in the Russian Silver age, a vibrant cultural renaissance.

In this article we investigate the nature of problem presentation and responses on an online forum for young people who self-harm. Previous studies have raised concerns about the peer encouragement of self-harming behaviours in online forums, and this analysis considers the nature of peer interaction on a specific forum, ‘ SharpTalk’. This was a research forum which explored the potential of online communities to foster engagement and shared learning between NHS professionals and young people who self-harm. This analysis draws on (...) conversation analysis methods to study problem presentation and responses, and nature of advice given. Analysis highlighted both the tendency to offer advice where it was not asked for, and the mundane ‘safe’ nature of advice. This awareness of how young people interact and provide support online is important for those setting up online interventions to support young people who self-harm. (shrink)

The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of (...) potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a ‘report’ button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them. (shrink)

Preanalytically, we are all scientific realists. But both philosophers and scientists become uncomfortable when forced into analysis. In the case of scientists, this discomfort often arises from practical difficulties in setting out a carefully described set of objects which adequately account for the phenomena with which they are concerned. This paper offers a set of representative examples of these difficulties for contemporary physicists. These examples challenge the traditional realist vision of mature scientific activity as struggling toward an ontologically well-defined world (...) picture. They challenge antirealist alternatives as well. (shrink)

A comprehensive evidentiary regime that would encompass adaptations, exaptations, spandrels, and constraints requires both a standard to be satisfied and a predesignated default presumption to be maintained before the standard is satisfied. Andrews et al. focus principally on the former component. Some thoughts are here offered on the latter.

The argument for unifying behavioral sciences can be enhanced by highlighting concrete, vivid, and useful benefits that coherent behavioral models could provide. Shifting sets of behavioral assumptions underlie every legal system's efforts to modify behaviors by changing incentives in the legal environment. Consequently, where those assumptions are flawed, improved behavioral models could improve law's effectiveness and efficiency in regulating behavior. (Published Online April 27 2007).

Superoxide is produced by a NADPH oxidase of phagocytic cells and contributes to their microbicidal activities. The oxidase is activated when receptors in the neutrophil plasma membrane bind to the target microbe. These receptors recognise antibodies and complement fragments which coat the target cell. The oxidase electron transport chain, located in the plasma membrane, comprises a low potential cytochrome b heterodimer (gp 91‐phox and p22‐phox) associated with FAD. It is non‐functional until at least three proteins, p67‐phox, p47‐phox and p21rac (and (...) possibly others), move from the cytosol to dock on the cytochrome b. The docking involves the interaction of SH3 domains may become exposed follwoing phosphorylation of p47‐phox by protein kinase C or, in model systems, by addition of arachidonic acid to reconstitution mixtures. Following the docking process the electron‐transporting component is able to transfer electrons from NADPH to oxygen. This electrogenic event is charge‐compensated by the opening of a prton channel. Components of the oxidase are expressed in non‐phagocytes, where their function is uncretain but could be related to some signal function of superoxide. (shrink)

Among the principles that are generally taken to underlie the general theory of relativity is a general principle of relativity. Such a principle is supposed to extend the special principle of relativity, which holds observers in uniform motion to be indistinguishable by appeal to the laws of physics, to a requirement on observers in arbitrary states of motion. Starting with physical intuitions described graphically by Galileo, proceeding through a series of formal requirements on reference frames defined on models of space-time (...) theories, and considering other "observations" commonly associated with relativity principles, this paper argues that the general principle of relativity is neither justified by "fact", nor exemplified by the general theory of relativity. (shrink)

Idiopathic Parkinson’s disease impairs working memory, but the exact nature of this deficit in terms of the underlying cognitive mechanisms is not well understood. In this study patients with mild clinical symptoms of PD were compared with matched healthy control subjects on a computerized battery of tests designed to assess spatial working memory and verbal working memory. In the spatial working memory task, subjects were required to recall a sequence of four locations. The verbal working memory task was methodologically identical (...) except for the modality of the stimuli used, requiring subjects to orally recall a sequence of six digits. In either case, half of the sequences were structured in a way that allowed ‘chunking’, while others were unstructured. This manipulation was designed to dissociate the strategic component of task performance from the memory-load component. Mild medicated patients with PD were impaired only on the structured versions of the verbal working memory tasks. The analogous deficit in the spatial working memory was less pronounced. These findings are in agreement with the hypothesis that working memory deficits in PD reflect mainly the executive component of the tasks and that the deficits may be at least partly modality-independent. (shrink)

Herbert McCabe, OP (d. 2001), was a significant theological figure in England in the last century. A scholar of Aquinas, he was also influenced by Wittgenstein and Marx, his reading of whom helped him articulate a distinctive Thomistic account of human embodiment that serves as a critique of other dominant approaches in ethics. This article shows McCabe's contribution to moral theology by placing his work in conversation with other important approaches, namely, situation ethics, proportionalism, and the New Natural Law Theory.

Pre-analytically, we are all scientific realists. But both philosophers and scientists become uncomfortable when forced into analysis. In the case of scientists, this discomfort often arises from quite practical difficulties in setting out a carefully described set of objects and their properties which adequately account at least for the phenomena with which they and those in their research specialty are concerned. I offer a set of representative examples of these difficulties for contemporary physicists. These examples challenge the traditional realist vision (...) of mature scientific activity as struggling toward a clear and ontologically well-defined world picture. (shrink)

John Earman's A Primer on Determinism treats the doctrine of Laplacian determinism by a careful look at a considerable variety of physical theories. This paper enriches Earman's discussion of chaos theory by considering in some detail the analysis of dripping faucets due to Robert Shaw. Shaw's analysis exhibits in a nice way some of the techniques used in chaos theory and gives a feel for research in this area. The paper concentrates on the tension between the determinism inherent in any (...) description involving differential equations and the in-practice unpredictability resulting from the extreme sensitivity to initial conditions of the non-linear differential equations characteristic of chaos theory. (shrink)

In a paper fifteen years ago about the meaning and the possibility of the beginning and end of time, our redoubtable session chair, John Earman, ended up like this:…[T]he answers to the questions posed at the outset lie somewhere in a thicket of problems growing out of the intersection of mathematics, physics, and metaphysics. This paper has only located the thicket and engaged in a little initial bush beating. This is not much progress, but knowing which bushes to beat is (...) a necessary first step.Some philosophers will be disappointed that the thicket is populated by so many problems of a technical and scientific nature. On the contrary, I am encouraged by this result because it shows that a long-standing philosophical problem has a nontrivial and, indeed, a surprisingly large content. Moreover, this result is a good illustration of the artificiality and danger of trying to separate philosophy from science. (Earman 1977, p. 131-2)These remarks are a kind of manifesto of an approach to philosophical questions about space and time dating from the late 1960’s. (shrink)